Overactive adrenal gland symptoms4/28/2023 ![]() Statistics suggest it affects about 10 to 15 people per million globally. Genetics Home Reference note that it usually appears in adults between the ages of 20 and 50 years, but it can affect children, too. Most of the time, it is unclear why it happens. Sometimes, the tumors form because of certain genetic changes or syndromes. These high levels of ACTH trigger high levels of cortisol, resulting in a range of symptoms. This is a rare condition that happens when a pituitary adenoma - a non-cancerous tumor in the pituitary gland - releases high levels of a hormone known as adrenocorticotropic hormone (ACTH). One cause of Cushing’s syndrome is Cushing’s disease. Share on Pinterest In Cushing syndrome, too much cortisol in the body results in a range of symptoms.
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